BCO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0016121Biological processcarotene catabolic process
GO_0016124Biological processxanthophyll catabolic process
GO_1901826Biological processzeaxanthin catabolic process
GO_0042573Biological processretinoic acid metabolic process
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0062172Biological processlutein catabolic process
GO_0042574Biological processretinal metabolic process
GO_0016116Biological processcarotenoid metabolic process
GO_1901176Biological processlycopene catabolic process
GO_0016119Biological processcarotene metabolic process
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0003834Molecular functionbeta-carotene 15,15'-dioxygenase activity
GO_0102076Molecular functionbeta,beta-carotene-9',10'-cleaving oxygenase activity
GO_0010437Molecular function9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
GO_0010436Molecular functioncarotenoid dioxygenase activity
GO_0046872Molecular functionmetal ion binding
GO_0016702Molecular functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IV. Literature review

[source]
Gene nameBCO2
Protein nameBeta-carotene oxygenase 2
Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.-) (EC 1.13.11.71) (B-diox-II) (Beta,beta-carotene 9',10'-oxygenase) (Beta-carotene dioxygenase 2)
Carotenoid-cleaving dioxygenase, mitochondrial (EC 1.13.11.71)
SynonymsBCDO2
DescriptionFUNCTION: Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules. .

AccessionsENST00000531169.5 [Q9BYV7-2]
E9PS89
H0YCN8
ENST00000361053.8 [Q9BYV7-5]
V9GYA9
ENST00000532593.5 [Q9BYV7-6]
ENST00000357685.11 [Q9BYV7-1]
ENST00000526088.5 [Q9BYV7-4]
ENST00000438022.5 [Q9BYV7-2]
H0YCL7
E9PPP9
Q9BYV7
ENST00000530677.1
ENST00000527939.1
ENST00000531003.1
ENST00000525175.1
ENST00000532612.5
ENST00000534550.5