Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 13 studies | 40% ± 12% | |
| mesothelial cell | 9 studies | 47% ± 15% | |
| myofibroblast cell | 8 studies | 39% ± 13% | |
| smooth muscle cell | 8 studies | 29% ± 12% | |
| pericyte | 6 studies | 34% ± 9% | |
| fibroblast | 5 studies | 23% ± 5% | |
| astrocyte | 4 studies | 23% ± 5% | |
| hepatocyte | 3 studies | 32% ± 11% | |
| oligodendrocyte | 3 studies | 19% ± 2% |
Insufficient scRNA-seq data for expression of BCHE at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 89% | 460.63 | 2352 / 2642 | 99% | 100.13 | 700 / 705 |
| liver | 97% | 2626.66 | 220 / 226 | 70% | 37.48 | 285 / 406 |
| skin | 69% | 289.04 | 1255 / 1809 | 80% | 59.90 | 379 / 472 |
| lung | 93% | 789.48 | 535 / 578 | 24% | 6.41 | 273 / 1155 |
| uterus | 98% | 1924.75 | 167 / 170 | 14% | 5.21 | 65 / 459 |
| esophagus | 74% | 2022.77 | 1069 / 1445 | 23% | 6.03 | 43 / 183 |
| intestine | 87% | 1780.23 | 836 / 966 | 5% | 0.85 | 28 / 527 |
| adrenal gland | 35% | 142.94 | 90 / 258 | 49% | 25.67 | 112 / 230 |
| spleen | 77% | 243.65 | 186 / 241 | 0% | 0 | 0 / 0 |
| bladder | 67% | 387.19 | 14 / 21 | 8% | 1.79 | 41 / 504 |
| breast | 60% | 221.34 | 276 / 459 | 5% | 8.40 | 53 / 1118 |
| prostate | 41% | 259.40 | 101 / 245 | 22% | 3.14 | 110 / 502 |
| adipose | 57% | 1239.83 | 692 / 1204 | 0% | 0 | 0 / 0 |
| heart | 57% | 296.93 | 493 / 861 | 0% | 0 | 0 / 0 |
| kidney | 16% | 42.73 | 14 / 89 | 27% | 8.61 | 247 / 901 |
| stomach | 35% | 245.19 | 126 / 359 | 5% | 2.12 | 13 / 286 |
| thymus | 22% | 59.91 | 145 / 653 | 11% | 3.85 | 67 / 605 |
| eye | 0% | 0 | 0 / 0 | 28% | 6.69 | 22 / 80 |
| ovary | 17% | 270.31 | 31 / 180 | 8% | 1.32 | 33 / 430 |
| blood vessel | 17% | 75.89 | 221 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 2% | 3.39 | 5 / 328 | 12% | 1.65 | 22 / 178 |
| muscle | 6% | 14.12 | 50 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.32 | 2 / 45 |
| peripheral blood | 2% | 6.99 | 19 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0007612 | Biological process | learning |
| GO_0016486 | Biological process | peptide hormone processing |
| GO_0043279 | Biological process | response to alkaloid |
| GO_0050805 | Biological process | negative regulation of synaptic transmission |
| GO_0050783 | Biological process | cocaine metabolic process |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0006581 | Biological process | acetylcholine catabolic process |
| GO_0014016 | Biological process | neuroblast differentiation |
| GO_0019695 | Biological process | choline metabolic process |
| GO_0051593 | Biological process | response to folic acid |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005641 | Cellular component | nuclear envelope lumen |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0033265 | Molecular function | choline binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0004104 | Molecular function | cholinesterase activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0003824 | Molecular function | catalytic activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0003990 | Molecular function | acetylcholinesterase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0016788 | Molecular function | hydrolase activity, acting on ester bonds |
| Gene name | BCHE |
| Protein name | Butyrylcholinesterase Carboxylic ester hydrolase (EC 3.1.1.-) Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE protein (Butyrylcholinesterase, isoform CRA_a) |
| Synonyms | hCG_14822 CHE1 |
| Description | FUNCTION: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. . FUNCTION: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. . FUNCTION: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. . |
| Accessions | F8WF14 H7C4Y0 H0Y885 P06276 ENST00000479451.5 ENST00000482958.1 ENST00000497011.5 ENST00000488954.1 ENST00000264381.8 Q96HL2 F8WEX7 |
