BCDIN3D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BCDIN3D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BCDIN3D at tissue level.

III. Associated gene sets

GO_2000632Biological processnegative regulation of pre-miRNA processing
GO_0001510Biological processRNA methylation
GO_0031054Biological processpre-miRNA processing
GO_0030488Biological processtRNA methylation
GO_0010586Biological processmiRNA metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008171Molecular functionO-methyltransferase activity
GO_0008173Molecular functionRNA methyltransferase activity
GO_0090486Molecular functionsmall RNA 2'-O-methyltransferase activity
GO_0070883Molecular functionpre-miRNA binding
GO_0008175Molecular functiontRNA methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBCDIN3D
Protein nameRNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein)
Synonyms
DescriptionFUNCTION: O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 . Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing . The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 . Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 . .

AccessionsQ7Z5W3
ENST00000333924.6