BAAT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008206Biological processbile acid metabolic process
GO_0006544Biological processglycine metabolic process
GO_0002152Biological processbile acid conjugation
GO_0001889Biological processliver development
GO_0031100Biological processanimal organ regeneration
GO_0006631Biological processfatty acid metabolic process
GO_0019530Biological processtaurine metabolic process
GO_0006637Biological processacyl-CoA metabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0047963Molecular functionglycine N-choloyltransferase activity
GO_0052689Molecular functioncarboxylic ester hydrolase activity
GO_0052817Molecular functionvery long-chain fatty acyl-CoA hydrolase activity
GO_0016746Molecular functionacyltransferase activity
GO_0052815Molecular functionmedium-chain fatty acyl-CoA hydrolase activity
GO_0047617Molecular functionfatty acyl-CoA hydrolase activity
GO_0016410Molecular functionN-acyltransferase activity
GO_0033882Molecular functioncholoyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBAAT
Protein nameBile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)
Bile acid-CoA:amino acid N-acyltransferase
Synonyms
DescriptionFUNCTION: Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine . More than 95% of the BAs are N-acyl amidates with glycine and taurine . Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism . This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption . May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids . In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs . .

AccessionsENST00000674791.1
ENST00000621712.2
Q14032
A0A6Q8PF60
ENST00000674909.1
A0A6Q8PHR9
ENST00000395051.4
ENST00000674556.1
ENST00000259407.7