B3GNT3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of B3GNT3 at tissue level.

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0030311Biological processpoly-N-acetyllactosamine biosynthetic process
GO_0006493Biological processprotein O-linked glycosylation
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005886Cellular componentplasma membrane
GO_0008499Molecular functionUDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO_0047223Molecular functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
GO_0008532Molecular functionN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

IV. Literature review

[source]
Gene nameB3GNT3
Protein nameN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Beta3GalT8) (b3Gal-T8) (Beta-3-Gx-T8) (Core 1 extending beta-1,3-N-acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Transmembrane protein 3) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) (BGnT-3) (Beta-1,3-Gn-T3) (Beta-1,3-N-acetylglucosaminyltransferase 3) (Beta3Gn-T3) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8)
Hexosyltransferase (EC 2.4.1.-)
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
SynonymsTMEM3
UNQ637/PRO1266
B3GALT8
DescriptionFUNCTION: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides . Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans . .

AccessionsENST00000599265.5
Q9Y2A9
ENST00000600777.1
ENST00000595387.1
M0QX58
M0R199
ENST00000318683.7