B3GAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0050650Biological processchondroitin sulfate proteoglycan biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0008542Biological processvisual learning
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0015018Molecular functiongalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

IV. Literature review

[source]
Gene nameB3GAT1
Protein nameGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)
SynonymsGLCATP
DescriptionFUNCTION: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. .

AccessionsENST00000524765.1 [Q9P2W7-1]
ENST00000392580.5 [Q9P2W7-1]
ENST00000312527.9 [Q9P2W7-1]
Q9P2W7