AURKC | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of AURKC at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	141.81	2598 / 2642	92%	3.21	646 / 705
thymus	100%	134.22	652 / 653	90%	3.42	543 / 605
adrenal gland	99%	91.51	256 / 258	81%	2.57	187 / 230
breast	100%	129.46	458 / 459	79%	2.20	880 / 1118
pancreas	88%	44.18	289 / 328	88%	2.53	157 / 178
prostate	100%	115.09	244 / 245	74%	1.26	372 / 502
bladder	100%	113.90	21 / 21	71%	2.32	360 / 504
uterus	99%	77.02	168 / 170	73%	1.73	333 / 459
lung	100%	155.19	576 / 578	70%	1.60	812 / 1155
skin	99%	98.12	1788 / 1809	69%	2.03	326 / 472
kidney	100%	112.67	89 / 89	67%	1.42	603 / 901
esophagus	100%	104.38	1439 / 1445	65%	1.43	119 / 183
liver	99%	82.84	224 / 226	53%	1.23	216 / 406
ovary	91%	63.40	164 / 180	51%	1.26	221 / 430
stomach	96%	63.06	343 / 359	42%	0.91	119 / 286
intestine	100%	107.19	963 / 966	36%	0.68	192 / 527
lymph node	0%	0	0 / 0	100%	4.45	29 / 29
spleen	100%	256.90	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	15.51	1 / 1
adipose	100%	123.38	1203 / 1204	0%	0	0 / 0
muscle	100%	102.42	799 / 803	0%	0	0 / 0
blood vessel	99%	92.45	1322 / 1335	0%	0	0 / 0
heart	97%	100.23	839 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	1.48	37 / 45
peripheral blood	61%	29.76	569 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	43%	0.86	34 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0007052	Biological process	mitotic spindle organization
GO_0051301	Biological process	cell division
GO_0051321	Biological process	meiotic cell cycle
GO_0051256	Biological process	mitotic spindle midzone assembly
GO_0006468	Biological process	protein phosphorylation
GO_0032467	Biological process	positive regulation of cytokinesis
GO_0032465	Biological process	regulation of cytokinesis
GO_0005876	Cellular component	spindle microtubule
GO_0030496	Cellular component	midbody
GO_0031616	Cellular component	spindle pole centrosome
GO_0000776	Cellular component	kinetochore
GO_0032133	Cellular component	chromosome passenger complex
GO_0051233	Cellular component	spindle midzone
GO_0005737	Cellular component	cytoplasm
GO_0000793	Cellular component	condensed chromosome
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0004712	Molecular function	protein serine/threonine/tyrosine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	AURKC
Protein name	Aurora kinase (EC 2.7.11.1) Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) Aurora kinase C
Synonyms	STK13 ARK3 AIE2 AIK3 AIRK3
Description	FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. .
Accessions	Q5Y191 M0QYK8 ENST00000302804.12 [Q9UQB9-1] ENST00000601799.5 B4DXA6 ENST00000594599.1 ENST00000598785.5 [Q9UQB9-2] M0QX60 ENST00000596375.1 Q9UQB9 ENST00000599062.5 ENST00000415300.6 [Q9UQB9-3]

AURKC report