ATPSCKMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904058Biological processpositive regulation of sensory perception of pain
GO_1905706Biological processregulation of mitochondrial ATP synthesis coupled proton transport
GO_1905273Biological processpositive regulation of proton-transporting ATP synthase activity, rotational mechanism
GO_0018023Biological processpeptidyl-lysine trimethylation
GO_0006338Biological processchromatin remodeling
GO_0018022Biological processpeptidyl-lysine methylation
GO_0030061Cellular componentmitochondrial crista
GO_0005739Cellular componentmitochondrion
GO_0042054Molecular functionhistone methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity

IV. Literature review

[source]
Gene nameATPSCKMT
Protein nameATP synthase subunit C lysine N-methyltransferase (EC 2.1.1.-) (Protein N-lysine methyltransferase FAM173B) (hFAM173B)
ATP synthase c subunit lysine N-methyltransferase
SynonymsLOC134145
hCG_36858
FAM173B
DescriptionFUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration . Promotes chronic pain . Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia . .

AccessionsJ3KN90
ENST00000280330.12
ENST00000504390.5
D6RBE3
D6RIE0
ENST00000511437.6 [Q6P4H8-1]
ENST00000510047.5 [Q6P4H8-2]
ENST00000506108.2
Q6P4H8