ATP4B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATP4B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP4B at tissue level.

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0036376Biological processsodium ion export across plasma membrane
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0007155Biological processcell adhesion
GO_0045851Biological processpH reduction
GO_0030007Biological processintracellular potassium ion homeostasis
GO_0032496Biological processresponse to lipopolysaccharide
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0010243Biological processresponse to organonitrogen compound
GO_0071805Biological processpotassium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005889Cellular componentpotassium:proton exchanging ATPase complex
GO_0005890Cellular componentsodium:potassium-exchanging ATPase complex
GO_0005886Cellular componentplasma membrane
GO_1901363Molecular functionheterocyclic compound binding
GO_0005515Molecular functionprotein binding
GO_0001671Molecular functionATPase activator activity
GO_0008900Molecular functionP-type potassium:proton transporter activity

IV. Literature review

[source]
Gene nameATP4B
Protein namePotassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)
Synonyms
DescriptionFUNCTION: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity). .

AccessionsENST00000335288.5
P51164