ATP4A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATP4A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP4A at tissue level.

III. Associated gene sets

GO_0036376Biological processsodium ion export across plasma membrane
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0071805Biological processpotassium ion transmembrane transport
GO_0045851Biological processpH reduction
GO_0010248Biological processestablishment or maintenance of transmembrane electrochemical gradient
GO_0010155Biological processregulation of proton transport
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0030007Biological processintracellular potassium ion homeostasis
GO_1902600Biological processproton transmembrane transport
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005889Cellular componentpotassium:proton exchanging ATPase complex
GO_0008900Molecular functionP-type potassium:proton transporter activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005391Molecular functionP-type sodium:potassium-exchanging transporter activity
GO_0030955Molecular functionpotassium ion binding
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP4A
Protein namePotassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
ATPase H+/K+ transporting subunit alpha
Synonyms
DescriptionFUNCTION: The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). .

AccessionsENST00000262623.4
M0R249
P20648
ENST00000592767.2