ATP2A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATP2A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP2A1 at tissue level.

III. Associated gene sets

GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0032470Biological processpositive regulation of endoplasmic reticulum calcium ion concentration
GO_0032471Biological processnegative regulation of endoplasmic reticulum calcium ion concentration
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_1902082Biological processpositive regulation of calcium ion import into sarcoplasmic reticulum
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0031448Biological processpositive regulation of fast-twitch skeletal muscle fiber contraction
GO_1990036Biological processcalcium ion import into sarcoplasmic reticulum
GO_0051561Biological processpositive regulation of mitochondrial calcium ion concentration
GO_0070509Biological processcalcium ion import
GO_0008637Biological processapoptotic mitochondrial changes
GO_0070588Biological processcalcium ion transmembrane transport
GO_0051659Biological processmaintenance of mitochondrion location
GO_1901896Biological processpositive regulation of ATPase-coupled calcium transmembrane transporter activity
GO_0106134Biological processpositive regulation of cardiac muscle cell contraction
GO_1903779Biological processregulation of cardiac conduction
GO_0006816Biological processcalcium ion transport
GO_0090076Biological processrelaxation of skeletal muscle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0034704Cellular componentcalcium channel complex
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0031095Cellular componentplatelet dense tubular network membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0030899Molecular functioncalcium-dependent ATPase activity
GO_0005388Molecular functionP-type calcium transporter activity
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP2A1
Protein nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Synonyms
DescriptionFUNCTION: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction . .

AccessionsH3BUT9
H3BVB2
ENST00000563975.1
ENST00000564470.1
ENST00000564732.1
ENST00000395503.9 [O14983-2]
ENST00000562185.5
ENST00000357084.7 [O14983-1]
H3BUU3
O14983
H3BTW4
ENST00000564112.1
H3BTF1
ENST00000536376.5 [O14983-3]