Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 8 studies | 28% ± 3% | |
| retinal ganglion cell | 6 studies | 64% ± 33% | |
| GABAergic neuron | 6 studies | 36% ± 24% | |
| glutamatergic neuron | 5 studies | 46% ± 26% | |
| neuron | 4 studies | 29% ± 4% | |
| endothelial cell | 4 studies | 26% ± 5% | |
| epithelial cell | 4 studies | 23% ± 8% | |
| interneuron | 3 studies | 36% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 36% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 4663.30 | 328 / 328 | 100% | 39.59 | 178 / 178 |
| brain | 100% | 9059.29 | 2640 / 2642 | 100% | 61.03 | 703 / 705 |
| uterus | 100% | 2020.35 | 170 / 170 | 100% | 40.19 | 457 / 459 |
| esophagus | 99% | 2306.80 | 1437 / 1445 | 100% | 60.39 | 183 / 183 |
| intestine | 100% | 2304.63 | 966 / 966 | 99% | 59.85 | 523 / 527 |
| ovary | 99% | 1479.28 | 179 / 180 | 100% | 41.70 | 429 / 430 |
| thymus | 100% | 3046.18 | 651 / 653 | 100% | 30.34 | 602 / 605 |
| skin | 99% | 2553.07 | 1798 / 1809 | 100% | 76.30 | 470 / 472 |
| stomach | 99% | 2322.27 | 357 / 359 | 99% | 55.27 | 283 / 286 |
| breast | 100% | 2508.34 | 457 / 459 | 99% | 52.69 | 1103 / 1118 |
| bladder | 100% | 2191.71 | 21 / 21 | 98% | 47.97 | 492 / 504 |
| lung | 99% | 3116.14 | 573 / 578 | 98% | 40.26 | 1133 / 1155 |
| prostate | 98% | 2673.63 | 241 / 245 | 99% | 43.95 | 496 / 502 |
| kidney | 100% | 2563.04 | 89 / 89 | 95% | 27.38 | 857 / 901 |
| adrenal gland | 100% | 2880.33 | 258 / 258 | 94% | 32.76 | 217 / 230 |
| eye | 0% | 0 | 0 / 0 | 100% | 56.15 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 46.68 | 29 / 29 |
| spleen | 100% | 4562.48 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 39.68 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 26.52 | 1 / 1 |
| adipose | 99% | 2334.40 | 1194 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 94% | 1557.49 | 1250 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 86% | 1415.53 | 693 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 82% | 1539.78 | 764 / 929 | 0% | 0 | 0 / 0 |
| liver | 26% | 290.42 | 59 / 226 | 45% | 8.56 | 182 / 406 |
| heart | 70% | 878.32 | 605 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000152 | Biological process | regulation of ubiquitin-specific protease activity |
| GO_0010821 | Biological process | regulation of mitochondrion organization |
| GO_0016243 | Biological process | regulation of autophagosome size |
| GO_1904714 | Biological process | regulation of chaperone-mediated autophagy |
| GO_0061909 | Biological process | autophagosome-lysosome fusion |
| GO_0033157 | Biological process | regulation of intracellular protein transport |
| GO_1990938 | Biological process | peptidyl-aspartic acid autophosphorylation |
| GO_1905166 | Biological process | negative regulation of lysosomal protein catabolic process |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0007041 | Biological process | lysosomal transport |
| GO_0071294 | Biological process | cellular response to zinc ion |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_1905165 | Biological process | regulation of lysosomal protein catabolic process |
| GO_1903710 | Biological process | spermine transmembrane transport |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_1903543 | Biological process | positive regulation of exosomal secretion |
| GO_1902047 | Biological process | polyamine transmembrane transport |
| GO_0043523 | Biological process | regulation of neuron apoptotic process |
| GO_0071287 | Biological process | cellular response to manganese ion |
| GO_0097734 | Biological process | extracellular exosome biogenesis |
| GO_1903146 | Biological process | regulation of autophagy of mitochondrion |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_1905037 | Biological process | autophagosome organization |
| GO_0034599 | Biological process | cellular response to oxidative stress |
| GO_0061462 | Biological process | protein localization to lysosome |
| GO_0006879 | Biological process | intracellular iron ion homeostasis |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_0006882 | Biological process | intracellular zinc ion homeostasis |
| GO_0030003 | Biological process | intracellular monoatomic cation homeostasis |
| GO_0006914 | Biological process | autophagy |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0016241 | Biological process | regulation of macroautophagy |
| GO_1900180 | Biological process | regulation of protein localization to nucleus |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0052548 | Biological process | regulation of endopeptidase activity |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0031982 | Cellular component | vesicle |
| GO_0016020 | Cellular component | membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0000421 | Cellular component | autophagosome membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005771 | Cellular component | multivesicular body |
| GO_0005770 | Cellular component | late endosome |
| GO_0005776 | Cellular component | autophagosome |
| GO_0030133 | Cellular component | transport vesicle |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0032585 | Cellular component | multivesicular body membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0019829 | Molecular function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| GO_1903135 | Molecular function | cupric ion binding |
| GO_0015417 | Molecular function | ABC-type polyamine transporter activity |
| GO_0030145 | Molecular function | manganese ion binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0015203 | Molecular function | polyamine transmembrane transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
| GO_0070300 | Molecular function | phosphatidic acid binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0015662 | Molecular function | P-type ion transporter activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ATP13A2 |
| Protein name | ATPase cation transporting 13A2 ATP13A2 protein Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) |
| Synonyms | PARK9 |
| Description | FUNCTION: ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine . Also stimulates cellular uptake of polyamines and protects against polyamine toxicity . Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity . Contributes to cellular zinc homeostasis . Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress . Required for proper lysosomal and mitochondrial maintenance . Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels . Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy . Promotes secretion of exosomes as well as secretion of SCNA via exosomes . Plays a role in lipid homeostasis . . |
| Accessions | H0YAI7 ENST00000503552.1 H0Y9K4 Q8N4D4 H0Y8Z6 H0Y953 Q9NQ11 ENST00000510069.5 ENST00000502418.1 ENST00000508222.5 H0Y9K0 ENST00000341676.9 [Q9NQ11-2] ENST00000506174.5 ENST00000511957.5 ENST00000509619.1 H0Y8I1 ENST00000452699.5 [Q9NQ11-3] H0Y8V5 ENST00000326735.13 [Q9NQ11-1] |
