ATG9A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATG9A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATG9A at tissue level.

III. Associated gene sets

GO_0060349Biological processbone morphogenesis
GO_0000045Biological processautophagosome assembly
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0097300Biological processprogrammed necrotic cell death
GO_0017121Biological processplasma membrane phospholipid scrambling
GO_0000422Biological processautophagy of mitochondrion
GO_0061709Biological processreticulophagy
GO_0031902Cellular componentlate endosome membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0055037Cellular componentrecycling endosome
GO_0031966Cellular componentmitochondrial membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0000421Cellular componentautophagosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005770Cellular componentlate endosome
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005768Cellular componentendosome
GO_0017128Molecular functionphospholipid scramblase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG9A
Protein nameAutophagy-related protein 9
Autophagy-related protein 9A (APG9-like 1) (mATG9)
Autophagy related 9A
SynonymsAPG9L1
DescriptionFUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion . Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome . Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion . Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 . In addition to autophagy, also plays a role in necrotic cell death (By similarity). .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. .

AccessionsC9JFV2
C9JD65
ENST00000432520.5
ENST00000431715.5
ENST00000409618.5 [Q7Z3C6-1]
ENST00000436856.5
Q7Z3C6
C9JKV7
ENST00000434939.1
ENST00000439812.5
C9JX27
C9JDK4
F2Z3I6
C9JXG2
ENST00000457841.5
ENST00000456708.5
H7C1G6
ENST00000409422.5 [Q7Z3C6-2]
ENST00000396761.6 [Q7Z3C6-1]
ENST00000428226.5
ENST00000361242.9 [Q7Z3C6-1]
ENST00000409033.7 [Q7Z3C6-3]
C9JS65
ENST00000412355.5
C9IYZ9
ENST00000443140.5
ENST00000429920.1