ATG4C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0015031Biological processprotein transport
GO_0016485Biological processprotein processing
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0006508Biological processproteolysis
GO_0006501Biological processC-terminal protein lipidation
GO_0035973Biological processaggrephagy
GO_0051697Biological processprotein delipidation
GO_0000045Biological processautophagosome assembly
GO_0005575Cellular componentcellular_component
GO_0005737Cellular componentcytoplasm
GO_0019786Molecular functionprotein-phosphatidylethanolamide deconjugating activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG4C
Protein nameCysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C)
Cysteine protease (EC 3.4.22.-)
SynonymsAUTL3
AUTL1
APG4C
DescriptionFUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins . The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine . Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins . Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy . Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity . In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy . .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

AccessionsQ96DT6
ENST00000371120.7
ENST00000317868.9
ENST00000443289.5
ENST00000414558.2
C9JC51
H7BZW5
A6NGQ4
Q05D29
ENST00000371118.1