ATG4A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATG4A at tissue level.

III. Associated gene sets

GO_0000423Biological processmitophagy
GO_0006914Biological processautophagy
GO_0015031Biological processprotein transport
GO_0016485Biological processprotein processing
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0006629Biological processlipid metabolic process
GO_0006508Biological processproteolysis
GO_0006501Biological processC-terminal protein lipidation
GO_0035973Biological processaggrephagy
GO_0051697Biological processprotein delipidation
GO_0000045Biological processautophagosome assembly
GO_0005737Cellular componentcytoplasm
GO_0019786Molecular functionprotein-phosphatidylethanolamide deconjugating activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG4A
Protein nameCysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A)
Cysteine protease (EC 3.4.22.-)
Autophagy related 4A cysteine peptidase
SynonymshCG_21686
APG4A
AUTL2
DescriptionFUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins . The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine . Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy . Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP . Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 . In addition to the protease activity, also mediates delipidation of ATG8 family proteins . Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy . Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity . Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy . .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. .

AccessionsF8W7J2
ENST00000394892.2
ENST00000372246.7
ENST00000345734.7 [Q8WYN0-2]
ENST00000457035.5
ENST00000343524.9
A0A0A0MT61
G5E979
H7BYM2
ENST00000372232.8 [Q8WYN0-1]
Q8WYN0