ATG16L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098792Biological processxenophagy
GO_0021766Biological processhippocampus development
GO_0000045Biological processautophagosome assembly
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0051607Biological processdefense response to virus
GO_0016236Biological processmacroautophagy
GO_0006501Biological processC-terminal protein lipidation
GO_0039689Biological processnegative stranded viral RNA replication
GO_0010508Biological processpositive regulation of autophagy
GO_0022038Biological processcorpus callosum development
GO_0016237Biological processmicroautophagy
GO_0015031Biological processprotein transport
GO_0000421Cellular componentautophagosome membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005930Cellular componentaxoneme
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0034274Cellular componentAtg12-Atg5-Atg16 complex
GO_0097225Cellular componentsperm midpiece
GO_0120095Cellular componentvacuole-isolation membrane contact site
GO_0036020Cellular componentendolysosome membrane
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0051020Molecular functionGTPase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG16L1
Protein nameAutophagy related 16 like 1 (Autophagy-related protein 16-1)
Autophagy-related protein 16-1 (APG16-like 1)
ATG16 autophagy related 16-like 1 (S. cerevisiae)
ATG16L1 protein
Autophagy-related protein 16-1 isoform 2
SynonymsUNQ9393/PRO34307
APG16L
DescriptionFUNCTION: Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) . Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling . During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 . Thereby, controls the elongation of the nascent autophagosomal membrane . Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 . Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production . Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response . Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 . Plays a role in regulating morphology and function of Paneth cell . .

AccessionsQ17RG0
ENST00000392020.8 [Q676U5-2]
ENST00000625501.3 [Q676U5-1]
ENST00000629673
D9N2U3
ENST00000392017.9 [Q676U5-1]
Q676U5
ENST00000392021.7
L7UQD0
C9J1B2
ENST00000347464.9 [Q676U5-5]
ENST00000431917.5
A5YM60
C9JAY7
ENST00000392018.1
ENST00000627513
ENST00000630066.2 [Q676U5-2]
C9JK97
ENST00000626639
ENST00000626623.2 [Q676U5-5]
D9N2U2
B7ZLM5
ENST00000444735.5
C9J8C6
ENST00000419681.5
ENST00000630204.2 [Q676U5-4]
ENST00000373525.9 [Q676U5-4]
ENST00000417017.5
E7EVC7
ENST00000631068
ENST00000630596
ENST00000629246
F8WAF9