ASTL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASTL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	56%	10.98	101 / 180	56%	2.01	240 / 430
spleen	98%	50.55	236 / 241	0%	0	0 / 0
lung	78%	18.52	450 / 578	12%	0.33	136 / 1155
bladder	62%	47.95	13 / 21	22%	0.58	109 / 504
peripheral blood	84%	57.06	776 / 929	0%	0	0 / 0
breast	49%	7.45	227 / 459	29%	0.66	324 / 1118
skin	72%	35.82	1306 / 1809	4%	0.06	18 / 472
prostate	58%	21.35	143 / 245	3%	0.08	16 / 502
intestine	49%	11.05	476 / 966	12%	0.31	64 / 527
stomach	45%	10.92	162 / 359	14%	0.27	39 / 286
brain	55%	12.50	1465 / 2642	1%	0.03	7 / 705
adipose	48%	7.53	576 / 1204	0%	0	0 / 0
esophagus	36%	5.13	527 / 1445	8%	0.14	15 / 183
uterus	30%	3.29	51 / 170	14%	0.41	66 / 459
kidney	38%	5.45	34 / 89	1%	0.01	7 / 901
lymph node	0%	0	0 / 0	38%	0.59	11 / 29
thymus	23%	3.28	147 / 653	14%	0.31	84 / 605
blood vessel	31%	6.11	419 / 1335	0%	0	0 / 0
heart	21%	2.18	177 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	18%	0.26	8 / 45
muscle	16%	1.34	126 / 803	0%	0	0 / 0
liver	12%	1.19	27 / 226	1%	0.01	3 / 406
adrenal gland	7%	0.78	17 / 258	6%	0.12	14 / 230
pancreas	9%	0.61	30 / 328	3%	0.08	6 / 178
eye	0%	0	0 / 0	5%	0.06	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0009566	Biological process	fertilization
GO_0007155	Biological process	cell adhesion
GO_2000360	Biological process	negative regulation of binding of sperm to zona pellucida
GO_0006508	Biological process	proteolysis
GO_0060468	Biological process	prevention of polyspermy
GO_0010954	Biological process	positive regulation of protein processing
GO_0005886	Cellular component	plasma membrane
GO_0060473	Cellular component	cortical granule
GO_0005737	Cellular component	cytoplasm
GO_0070001	Molecular function	aspartic-type peptidase activity
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0070002	Molecular function	glutamic-type peptidase activity

Gene name	ASTL
Protein name	Metalloendopeptidase (EC 3.4.24.-) Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase)
Synonyms
Description	FUNCTION: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. .
Accessions	Q3B826 ENST00000342380.3 Q6HA08

ASTL report