ASMTL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASMTL at tissue level.

III. Associated gene sets

GO_0032259Biological processmethylation
GO_0008150Biological processbiological_process
GO_0009117Biological processnucleotide metabolic process
GO_0005829Cellular componentcytosol
GO_0036221Molecular functionUTP diphosphatase activity
GO_0008171Molecular functionO-methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0047429Molecular functionnucleoside triphosphate diphosphatase activity
GO_0036218Molecular functiondTTP diphosphatase activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameASMTL
Protein nameProbable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)]
Synonyms
DescriptionFUNCTION: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP . May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids . In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). .

AccessionsO95671
ENST00000711197.1 [O95671-1]
ENST00000534940.6 [O95671-3]
ENST00000381333.9 [O95671-2]
ENST00000711192.1 [O95671-3]
ENST00000711196.1 [O95671-2]
ENST00000381317.9 [O95671-1]