Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 21% ± 5% | |
| epithelial cell | 4 studies | 26% ± 6% | |
| GABAergic neuron | 4 studies | 30% ± 9% | |
| astrocyte | 4 studies | 21% ± 4% | |
| glutamatergic neuron | 4 studies | 36% ± 13% | |
| adipocyte | 4 studies | 19% ± 3% | |
| transit amplifying cell | 3 studies | 23% ± 8% | |
| interneuron | 3 studies | 30% ± 13% | |
| neuron | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2373.82 | 1445 / 1445 | 100% | 29.06 | 183 / 183 |
| stomach | 100% | 1888.70 | 359 / 359 | 100% | 27.24 | 286 / 286 |
| uterus | 100% | 2515.16 | 170 / 170 | 100% | 34.44 | 459 / 459 |
| breast | 100% | 2666.11 | 459 / 459 | 100% | 59.25 | 1117 / 1118 |
| brain | 100% | 2264.19 | 2638 / 2642 | 100% | 34.44 | 705 / 705 |
| prostate | 100% | 1991.64 | 245 / 245 | 100% | 27.60 | 501 / 502 |
| pancreas | 100% | 1389.39 | 327 / 328 | 100% | 25.78 | 178 / 178 |
| thymus | 100% | 1745.85 | 653 / 653 | 100% | 30.20 | 603 / 605 |
| lung | 100% | 1817.85 | 576 / 578 | 100% | 35.81 | 1155 / 1155 |
| skin | 100% | 2508.29 | 1809 / 1809 | 100% | 43.50 | 470 / 472 |
| ovary | 100% | 2907.46 | 180 / 180 | 100% | 24.17 | 428 / 430 |
| intestine | 100% | 2273.57 | 966 / 966 | 99% | 25.62 | 524 / 527 |
| bladder | 100% | 2474.33 | 21 / 21 | 99% | 30.05 | 499 / 504 |
| kidney | 100% | 1651.98 | 89 / 89 | 98% | 24.41 | 885 / 901 |
| adrenal gland | 100% | 2151.48 | 258 / 258 | 97% | 21.66 | 222 / 230 |
| liver | 100% | 1091.72 | 226 / 226 | 85% | 12.59 | 345 / 406 |
| adipose | 100% | 2613.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2293.29 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 35.00 | 29 / 29 |
| spleen | 100% | 2302.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 37.81 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.84 | 1 / 1 |
| muscle | 100% | 2447.50 | 802 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 31.31 | 79 / 80 |
| peripheral blood | 98% | 1991.74 | 910 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 1605.82 | 843 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0006974 | Biological process | DNA damage response |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0043627 | Biological process | response to estrogen |
| GO_0045815 | Biological process | transcription initiation-coupled chromatin remodeling |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0048188 | Cellular component | Set1C/COMPASS complex |
| GO_0044665 | Cellular component | MLL1/2 complex |
| GO_0000791 | Cellular component | euchromatin |
| GO_0035097 | Cellular component | histone methyltransferase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0071339 | Cellular component | MLL1 complex |
| GO_0044666 | Cellular component | MLL3/4 complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| Gene name | ASH2L |
| Protein name | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) ASH2 like, histone lysine methyltransferase complex subunit |
| Synonyms | ASH2L1 |
| Description | FUNCTION: Transcriptional regulator . Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters . Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated . As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 . May play a role in hematopoiesis . In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B . . |
| Accessions | ENST00000517719.5 ENST00000521652.5 [Q9UBL3-2] E5RHM1 ENST00000343823.11 [Q9UBL3-1] ENST00000428278.6 [Q9UBL3-3] E5RFH5 F5H8F7 H0YAQ0 ENST00000545394.2 ENST00000521808.5 H0YBF6 ENST00000524247.5 Q9UBL3 ENST00000517496.5 |
