ASB1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ASB1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASB1 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0035556Biological processintracellular signal transduction
GO_0030539Biological processmale genitalia development
GO_0001818Biological processnegative regulation of cytokine production
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASB1
Protein nameAnkyrin repeat and SOCS box containing 1
Ankyrin repeat and SOCS box protein 1 (ASB-1)
SynonymsKIAA1146
DescriptionFUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 . May play a role in testis development (By similarity). .

AccessionsENST00000438264.5
B9A047
ENST00000409297.1
Q9Y576
F8WBM8
ENST00000264607.9