I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of ARPIN at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2663.85 | 1445 / 1445 | 100% | 15.33 | 183 / 183 |
| prostate | 100% | 2990.61 | 245 / 245 | 100% | 26.38 | 502 / 502 |
| brain | 100% | 2022.32 | 2641 / 2642 | 100% | 23.12 | 704 / 705 |
| intestine | 100% | 3535.77 | 966 / 966 | 100% | 15.50 | 526 / 527 |
| pancreas | 100% | 5355.27 | 328 / 328 | 99% | 15.01 | 177 / 178 |
| lung | 100% | 2604.25 | 578 / 578 | 99% | 17.07 | 1145 / 1155 |
| breast | 100% | 2682.78 | 459 / 459 | 99% | 18.96 | 1106 / 1118 |
| skin | 100% | 2737.08 | 1809 / 1809 | 99% | 16.83 | 466 / 472 |
| stomach | 100% | 1922.65 | 359 / 359 | 99% | 14.99 | 282 / 286 |
| uterus | 100% | 3612.66 | 170 / 170 | 98% | 16.81 | 452 / 459 |
| bladder | 100% | 2826.76 | 21 / 21 | 98% | 12.63 | 494 / 504 |
| kidney | 100% | 1824.66 | 89 / 89 | 98% | 15.44 | 882 / 901 |
| thymus | 100% | 2769.83 | 653 / 653 | 98% | 19.06 | 592 / 605 |
| ovary | 100% | 3344.88 | 180 / 180 | 97% | 10.90 | 419 / 430 |
| liver | 97% | 773.02 | 219 / 226 | 87% | 7.67 | 355 / 406 |
| adrenal gland | 99% | 1475.43 | 255 / 258 | 83% | 5.70 | 190 / 230 |
| adipose | 100% | 2879.28 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2572.66 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1372.33 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.46 | 1 / 1 |
| muscle | 100% | 1311.14 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1444.50 | 843 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 13.90 | 44 / 45 |
| eye | 0% | 0 | 0 / 0 | 98% | 9.85 | 78 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 59% | 3.70 | 17 / 29 |
| peripheral blood | 13% | 86.62 | 119 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_2000393 | Biological process | negative regulation of lamellipodium morphogenesis |
| GO_0033058 | Biological process | directional locomotion |
| GO_0051126 | Biological process | negative regulation of actin nucleation |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ARPIN |
| Protein name | Arpin Arpin (Arp2/3 inhibition protein) |
| Synonyms | C15orf38 |
| Description | FUNCTION: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. . |
| Accessions | Q7Z6K5 H0YL03 ENST00000560096.1 ENST00000460685.1 H0YMP5 ENST00000357484.10 [Q7Z6K5-1] |
