ARMC12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ARMC12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARMC12 at tissue level.

III. Associated gene sets

GO_0030317Biological processflagellated sperm motility
GO_0030307Biological processpositive regulation of cell growth
GO_0120317Biological processsperm mitochondrial sheath assembly
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARMC12
Protein nameArmadillo repeat-containing protein 12
Armadillo repeat containing 12
SynonymsC6orf81
DescriptionFUNCTION: Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (By similarity). Facilitates the growth and aggressiveness of neuroblastoma cells . Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells . .

AccessionsF8WC51
ENST00000471400.1
ENST00000373869.7 [Q5T9G4-3]
Q5T9G4
ENST00000288065.6 [Q5T9G4-2]
ENST00000373866.4 [Q5T9G4-1]