ARHGAP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007266Biological processRho protein signal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0030041Biological processactin filament polymerization
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0048041Biological processfocal adhesion assembly
GO_0015629Cellular componentactin cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0005884Cellular componentactin filament
GO_0016004Molecular functionphospholipase activator activity
GO_0043274Molecular functionphospholipase binding
GO_0005096Molecular functionGTPase activator activity
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameARHGAP6
Protein nameRho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)
Rho GTPase activating protein 6
Rho GTPase activating protein 6 (cDNA FLJ59725, highly similar to Rho-GTPase-activating protein 6)
SynonymsRHOGAP6
DescriptionFUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. .

AccessionsENST00000337414.9 [O43182-1]
O43182
ENST00000380718.1 [O43182-2]
ENST00000380736.5 [O43182-4]
ENST00000303025.10 [O43182-4]
ENST00000495242.5 [O43182-3]
H7BYE6
ENST00000380717.7
B4DN07
ENST00000657361.1