AQP11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AQP11 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0015793Biological processglycerol transmembrane transport
GO_0048388Biological processendosomal lumen acidification
GO_0072014Biological processproximal tubule development
GO_0006811Biological processmonoatomic ion transport
GO_0015840Biological processurea transport
GO_0080170Biological processhydrogen peroxide transmembrane transport
GO_0006612Biological processprotein targeting to membrane
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0006833Biological processwater transport
GO_1904293Biological processnegative regulation of ERAD pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032364Biological processintracellular oxygen homeostasis
GO_0009992Biological processintracellular water homeostasis
GO_0006486Biological processprotein glycosylation
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0015250Molecular functionwater channel activity
GO_0015267Molecular functionchannel activity
GO_0015254Molecular functionglycerol channel activity

IV. Literature review

[source]
Gene nameAQP11
Protein nameAquaporin-11 (AQP-11)
SynonymsAQPX1
PSEC0027
DescriptionFUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain . In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway . Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity). .

AccessionsENST00000313578.4
Q8NBQ7