AP4E1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008104Biological processprotein localization
GO_0016192Biological processvesicle-mediated transport
GO_0006886Biological processintracellular protein transport
GO_0006605Biological processprotein targeting
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0030124Cellular componentAP-4 adaptor complex
GO_0031904Cellular componentendosome lumen
GO_0140312Molecular functioncargo adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP4E1
Protein nameAP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)
Alternative protein AP4E1
Adaptor related protein complex 4 subunit epsilon 1
Synonyms
DescriptionFUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). .

AccessionsL8ECD9
ENST00000561441.5
Q9UPM8
ENST00000560508.1 [Q9UPM8-2]
ENST00000561393.5
H0YK94
ENST00000558439.5
H0YL95
ENST00000261842.10 [Q9UPM8-1]
H0YK95