AP4B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AP4B1 at tissue level.

III. Associated gene sets

GO_0008104Biological processprotein localization
GO_0016192Biological processvesicle-mediated transport
GO_0006886Biological processintracellular protein transport
GO_0061938Biological processprotein localization to somatodendritic compartment
GO_0006605Biological processprotein targeting
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0030124Cellular componentAP-4 adaptor complex
GO_0030131Cellular componentclathrin adaptor complex
GO_0005829Cellular componentcytosol
GO_0098541Cellular componentcytoplasmic side of trans-Golgi network transport vesicle membrane
GO_0031904Cellular componentendosome lumen
GO_0030276Molecular functionclathrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP4B1
Protein nameAP complex subunit beta
AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)
Adaptor related protein complex 4 subunit beta 1
Synonyms
DescriptionFUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). .

AccessionsENST00000369564.5
ENST00000256658.8 [Q9Y6B7-1]
B1ALD2
ENST00000432415.5
ENST00000369569.6 [Q9Y6B7-1]
ENST00000369571.2
ENST00000369567.5
B1ALD0
B1ALD1
B1ALD3
Q9Y6B7