AP1AR | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	27% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1099.87	1445 / 1445	100%	17.15	183 / 183
intestine	100%	1331.22	966 / 966	100%	17.82	526 / 527
brain	100%	1396.05	2636 / 2642	100%	11.96	705 / 705
breast	100%	1396.64	459 / 459	100%	23.12	1114 / 1118
lung	99%	1033.73	575 / 578	100%	12.59	1154 / 1155
stomach	100%	774.69	359 / 359	99%	16.10	284 / 286
bladder	100%	1262.52	21 / 21	99%	14.50	499 / 504
prostate	100%	923.85	245 / 245	98%	12.79	494 / 502
ovary	100%	1385.85	180 / 180	98%	7.52	422 / 430
kidney	100%	1200.76	89 / 89	98%	14.04	882 / 901
adrenal gland	100%	1538.64	258 / 258	98%	11.62	225 / 230
uterus	100%	1231.45	170 / 170	97%	12.36	447 / 459
pancreas	99%	584.16	324 / 328	98%	12.27	175 / 178
thymus	100%	1054.69	653 / 653	97%	9.01	584 / 605
skin	100%	1531.27	1809 / 1809	93%	12.91	438 / 472
liver	100%	975.96	226 / 226	89%	7.61	362 / 406
adipose	100%	1210.58	1204 / 1204	0%	0	0 / 0
spleen	100%	1085.76	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.84	1 / 1
blood vessel	100%	1174.69	1334 / 1335	0%	0	0 / 0
muscle	99%	581.65	792 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	12.84	43 / 45
heart	93%	531.03	803 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	9.58	27 / 29
eye	0%	0	0 / 0	68%	5.41	54 / 80
peripheral blood	48%	574.46	445 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1900025	Biological process	negative regulation of substrate adhesion-dependent cell spreading
GO_0015031	Biological process	protein transport
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0001920	Biological process	negative regulation of receptor recycling
GO_0034315	Biological process	regulation of Arp2/3 complex-mediated actin nucleation
GO_0048203	Biological process	vesicle targeting, trans-Golgi to endosome
GO_2000146	Biological process	negative regulation of cell motility
GO_0030133	Cellular component	transport vesicle
GO_0005768	Cellular component	endosome
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005770	Cellular component	late endosome
GO_0005769	Cellular component	early endosome
GO_0035650	Molecular function	AP-1 adaptor complex binding
GO_0019894	Molecular function	kinesin binding

Gene name	AP1AR
Protein name	AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) Adaptor related protein complex 1 associated regulatory protein
Synonyms	PRO0971 C4orf16
Description	FUNCTION: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. .
Accessions	H0Y8Y4 ENST00000309703.10 [Q63HQ0-2] ENST00000512741.1 Q63HQ0 ENST00000274000.10 [Q63HQ0-1]

AP1AR report