AOC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009445Biological processputrescine metabolic process
GO_0046677Biological processresponse to antibiotic
GO_0009308Biological processamine metabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0035580Cellular componentspecific granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005777Cellular componentperoxisome
GO_0005923Cellular componentbicellular tight junction
GO_0008201Molecular functionheparin binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0052597Molecular functiondiamine oxidase activity
GO_0052599Molecular functionmethylputrescine oxidase activity
GO_0008131Molecular functionprimary amine oxidase activity
GO_0050232Molecular functionputrescine oxidase activity
GO_0052598Molecular functionhistamine oxidase activity
GO_0048038Molecular functionquinone binding
GO_0052600Molecular functionpropane-1,3-diamine oxidase activity
GO_0005507Molecular functioncopper ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAOC1
Protein nameAmine oxidase (EC 1.4.3.-)
Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) (KDAO)
SynonymsDAO
ABP
ABP1
DescriptionFUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia . Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses . Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism . It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes . .

AccessionsENST00000483043.1
ENST00000493429.5 [P19801-1]
C9J0G8
C9J2J4
ENST00000467291.5 [P19801-1]
P19801
ENST00000460213.1
ENST00000360937.9 [P19801-1]
ENST00000416793.6 [P19801-2]