ANKZF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072344Biological processrescue of stalled ribosome
GO_0036503Biological processERAD pathway
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0004521Molecular functionRNA endonuclease activity
GO_0140101Molecular functioncatalytic activity, acting on a tRNA
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameANKZF1
Protein nametRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744)
Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
SynonymsZNF744
DescriptionFUNCTION: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation . The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts . ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs . ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 . Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress . .

AccessionsF8WD44
ENST00000410034.7
ENST00000436226.1
Q9H8Y5
C9K022
C9J5H7
ENST00000435521.5
C9JQZ3
ENST00000323348.10
ENST00000416565.1
ENST00000447157.5
ENST00000453432.5
B8ZZS4
ENST00000409849.5
C9JS61