ANAPC7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0016567Biological processprotein ubiquitination
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0051301Biological processcell division
GO_0051445Biological processregulation of meiotic cell cycle
GO_0007346Biological processregulation of mitotic cell cycle
GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0000792Cellular componentheterochromatin
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0140767Molecular functionenzyme-substrate adaptor activity
GO_0019903Molecular functionprotein phosphatase binding

IV. Literature review

[source]
Gene nameANAPC7
Protein nameAnaphase promoting complex subunit 7
Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)
ANAPC7 protein
SynonymsAPC7
DescriptionFUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains . APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates . Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis . .

AccessionsENST00000552170.2
Q9UJX3
A5D8X2
Q4KMX6
Q2M2R1
H0YIX7
ENST00000450008.3 [Q9UJX3-2]
H0YIW2
ENST00000455511.9 [Q9UJX3-1]
ENST00000552087.1
A8KAQ7