ALPL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALPL at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0055062Biological processphosphate ion homeostasis
GO_0036005Biological processresponse to macrophage colony-stimulating factor
GO_0001649Biological processosteoblast differentiation
GO_0032868Biological processresponse to insulin
GO_0001958Biological processendochondral ossification
GO_0034516Biological processresponse to vitamin B6
GO_0019725Biological processcellular homeostasis
GO_1904383Biological processresponse to sodium phosphate
GO_0140651Biological processfutile creatine cycle
GO_0051384Biological processresponse to glucocorticoid
GO_0046677Biological processresponse to antibiotic
GO_0030282Biological processbone mineralization
GO_0071529Biological processcementum mineralization
GO_0016311Biological processdephosphorylation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0140928Biological processinhibition of non-skeletal tissue mineralization
GO_0001501Biological processskeletal system development
GO_0042822Biological processpyridoxal phosphate metabolic process
GO_0003006Biological processdevelopmental process involved in reproduction
GO_0071407Biological processcellular response to organic cyclic compound
GO_0033280Biological processresponse to vitamin D
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0070062Cellular componentextracellular exosome
GO_0031012Cellular componentextracellular matrix
GO_0098552Cellular componentside of membrane
GO_0004427Molecular functioninorganic diphosphate phosphatase activity
GO_0033883Molecular functionpyridoxal phosphatase activity
GO_0004035Molecular functionalkaline phosphatase activity
GO_0052732Molecular functionphosphoethanolamine phosphatase activity
GO_0005509Molecular functioncalcium ion binding
GO_0016462Molecular functionpyrophosphatase activity
GO_0043262Molecular functionADP phosphatase activity
GO_0050187Molecular functionphosphoamidase activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameALPL
Protein namealkaline phosphatase (EC 3.1.3.1)
Alkaline phosphatase, tissue-nonspecific isozyme (EC 3.1.3.1) (EC 3.9.1.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase)
Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNS-ALP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)
Synonyms
DescriptionFUNCTION: Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis . Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates . Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration . Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters . Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) . Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). .

AccessionsENST00000374840.8 [P05186-1]
ENST00000540617.5 [P05186-3]
ENST00000374832.5 [P05186-1]
G8I0M6
ENST00000374830.2
B1ANL0
P05186
ENST00000539907.5 [P05186-2]