ALOXE3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ALOXE3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALOXE3 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_0043651Biological processlinoleic acid metabolic process
GO_0061436Biological processestablishment of skin barrier
GO_0034440Biological processlipid oxidation
GO_0019372Biological processlipoxygenase pathway
GO_0046513Biological processceramide biosynthetic process
GO_0006665Biological processsphingolipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0051122Biological processhepoxilin biosynthetic process
GO_0045444Biological processfat cell differentiation
GO_0005829Cellular componentcytosol
GO_0106255Molecular functionhydroperoxy icosatetraenoate isomerase activity
GO_0050486Molecular functionintramolecular hydroxytransferase activity
GO_0005506Molecular functioniron ion binding
GO_0051120Molecular functionhepoxilin A3 synthase activity
GO_0106256Molecular functionhydroperoxy icosatetraenoate dehydratase activity
GO_0005515Molecular functionprotein binding
GO_0016702Molecular functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IV. Literature review

[source]
Gene nameALOXE3
Protein nameHydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)
Arachidonate lipoxygenase 3, isoform CRA_a (Hydroperoxide isomerase ALOXE3)
SynonymshCG_31289
DescriptionFUNCTION: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity . The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones . In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides . In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins . Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss . In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites . Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). .

AccessionsENST00000380149
ENST00000448843.7 [Q9BYJ1-1]
J3KPH2
ENST00000318227.4 [Q9BYJ1-1]
ENST00000380149.6 [Q9BYJ1-1]
Q9BYJ1