ALOX12B | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALOX12B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	54%	68.07	132 / 245	50%	1.49	249 / 502
esophagus	33%	162.40	474 / 1445	67%	10.26	123 / 183
skin	72%	5303.01	1300 / 1809	13%	2.38	60 / 472
tonsil	0%	0	0 / 0	84%	10.99	38 / 45
brain	63%	50.44	1656 / 2642	18%	0.43	128 / 705
uterus	1%	20.02	2 / 170	42%	4.64	192 / 459
intestine	17%	9.65	165 / 966	20%	0.79	108 / 527
lung	2%	1.97	13 / 578	29%	1.41	339 / 1155
kidney	3%	1.38	3 / 89	25%	0.44	221 / 901
stomach	11%	12.01	41 / 359	16%	0.52	47 / 286
bladder	0%	0	0 / 21	19%	0.94	96 / 504
ovary	0%	0	0 / 180	15%	0.38	65 / 430
pancreas	1%	1.32	3 / 328	14%	0.34	25 / 178
adrenal gland	0%	0	0 / 258	14%	0.45	32 / 230
lymph node	0%	0	0 / 0	14%	0.17	4 / 29
breast	1%	0.32	3 / 459	6%	0.14	70 / 1118
thymus	0%	0.28	2 / 653	6%	0.53	36 / 605
liver	1%	0.98	2 / 226	1%	0.02	6 / 406
peripheral blood	2%	1.01	20 / 929	0%	0	0 / 0
spleen	1%	0.59	3 / 241	0%	0	0 / 0
adipose	1%	4.29	10 / 1204	0%	0	0 / 0
muscle	1%	2.02	5 / 803	0%	0	0 / 0
blood vessel	0%	2.40	5 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043651	Biological process	linoleic acid metabolic process
GO_0061436	Biological process	establishment of skin barrier
GO_0034440	Biological process	lipid oxidation
GO_0006497	Biological process	protein lipidation
GO_0019372	Biological process	lipoxygenase pathway
GO_0010628	Biological process	positive regulation of gene expression
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0046513	Biological process	ceramide biosynthetic process
GO_0006665	Biological process	sphingolipid metabolic process
GO_0019369	Biological process	arachidonic acid metabolic process
GO_0051122	Biological process	hepoxilin biosynthetic process
GO_0070257	Biological process	positive regulation of mucus secretion
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0106237	Molecular function	arachidonate 12(R)-lipoxygenase activity
GO_1990136	Molecular function	linoleate 9S-lipoxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0047677	Molecular function	arachidonate 8(R)-lipoxygenase activity
GO_0004052	Molecular function	arachidonate 12(S)-lipoxygenase activity
GO_0016853	Molecular function	isomerase activity
GO_0016829	Molecular function	lyase activity
GO_0016702	Molecular function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Gene name	ALOX12B
Protein name	Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) Arachidonate 12-lipoxygenase, 12R type
Synonyms
Description	FUNCTION: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species . In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins . Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss . May also play a role in the regulation of the expression of airway mucins . .
Accessions	ENST00000649809.1 A0A3B3IRK2 O75342 ENST00000647874.1

ALOX12B report