ALOX12 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALOX12 at tissue level.

III. Associated gene sets

GO_0043651Biological processlinoleic acid metabolic process
GO_0061436Biological processestablishment of skin barrier
GO_2001303Biological processlipoxin A4 biosynthetic process
GO_0034440Biological processlipid oxidation
GO_0042554Biological processsuperoxide anion generation
GO_0019395Biological processfatty acid oxidation
GO_0019372Biological processlipoxygenase pathway
GO_1901751Biological processleukotriene A4 metabolic process
GO_2001306Biological processlipoxin B4 biosynthetic process
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0033559Biological processunsaturated fatty acid metabolic process
GO_0006629Biological processlipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0051122Biological processhepoxilin biosynthetic process
GO_0010656Biological processnegative regulation of muscle cell apoptotic process
GO_0016020Cellular componentmembrane
GO_0042383Cellular componentsarcolemma
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0047977Molecular functionhepoxilin-epoxide hydrolase activity
GO_0050473Molecular functionarachidonate 15-lipoxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0004052Molecular functionarachidonate 12(S)-lipoxygenase activity
GO_0016165Molecular functionlinoleate 13S-lipoxygenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALOX12
Protein nameArachidonate 12-lipoxygenase, 12S type
Polyunsaturated fatty acid lipoxygenase ALOX12 (EC 1.13.11.-) (Arachidonate (12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Arachidonate (15S)-lipoxygenase) (EC 1.13.11.33) (Linoleate (13S)-lipoxygenase) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12)
SynonymsLOG12
12LO
DescriptionFUNCTION: Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species . Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE . Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation . It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA . Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets . An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites . Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic . Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells . .

AccessionsK7ENN9
P18054
ENST00000480801.1
ENST00000251535.11