ALKBH8 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	36% ± 1%	Explore
glutamatergic neuron	3 studies	40% ± 3%	Explore

Name	Number of supported studies	Average coverage
brain	4 studies	28% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	434.83	2634 / 2642	100%	9.47	705 / 705
breast	100%	618.32	459 / 459	99%	9.39	1110 / 1118
thymus	100%	614.51	653 / 653	99%	8.64	599 / 605
esophagus	100%	478.13	1444 / 1445	99%	6.40	181 / 183
prostate	100%	527.36	245 / 245	99%	6.12	495 / 502
bladder	100%	655.48	21 / 21	97%	5.89	488 / 504
lung	97%	401.92	562 / 578	99%	6.73	1140 / 1155
pancreas	98%	271.70	320 / 328	98%	6.64	174 / 178
stomach	100%	374.02	358 / 359	95%	5.71	271 / 286
intestine	100%	543.83	966 / 966	94%	5.74	497 / 527
uterus	100%	652.34	170 / 170	94%	5.55	431 / 459
kidney	100%	386.81	89 / 89	93%	6.13	840 / 901
adrenal gland	99%	425.86	256 / 258	92%	5.31	211 / 230
skin	100%	726.00	1808 / 1809	90%	7.16	424 / 472
ovary	100%	527.02	180 / 180	81%	3.31	347 / 430
liver	100%	298.61	226 / 226	78%	3.14	315 / 406
adipose	100%	601.36	1204 / 1204	0%	0	0 / 0
blood vessel	100%	646.61	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	8.44	29 / 29
spleen	100%	583.44	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.02	1 / 1
muscle	100%	589.12	802 / 803	0%	0	0 / 0
heart	97%	380.83	834 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	4.75	43 / 45
eye	0%	0	0 / 0	83%	4.98	66 / 80
peripheral blood	50%	242.68	462 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0002098	Biological process	tRNA wobble uridine modification
GO_0006974	Biological process	DNA damage response
GO_0030488	Biological process	tRNA methylation
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0000049	Molecular function	tRNA binding
GO_0016300	Molecular function	tRNA (uridine) methyltransferase activity
GO_0005506	Molecular function	iron ion binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0008757	Molecular function	S-adenosylmethionine-dependent methyltransferase activity
GO_0106335	Molecular function	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity
GO_0016706	Molecular function	2-oxoglutarate-dependent dioxygenase activity

Gene name	ALKBH8
Protein name	AlkB homolog 8, tRNA methyltransferase Alkylated DNA repair protein alkB homolog 8 (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229)
Synonyms	ABH8
Description	FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain . Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA . Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) . Required for normal survival after DNA damage . May inhibit apoptosis and promote cell survival and angiogenesis . .
Accessions	ENST00000417449.6 [Q96BT7-1] Q96BT7 ENST00000428149.7 [Q96BT7-1] C9JQN2 ENST00000389568.7 [Q96BT7-1] ENST00000260318.6 [Q96BT7-2] ENST00000393100.3 ENST00000429370.5 [Q96BT7-3]

ALKBH8 report