ALKBH4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALKBH4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	460.85	180 / 180	100%	16.40	430 / 430
skin	100%	598.34	1809 / 1809	100%	24.63	472 / 472
thymus	100%	688.99	653 / 653	100%	28.35	605 / 605
brain	100%	675.06	2641 / 2642	100%	32.16	705 / 705
uterus	100%	568.70	170 / 170	100%	21.78	458 / 459
kidney	100%	448.07	89 / 89	100%	17.66	897 / 901
liver	100%	289.46	226 / 226	99%	12.14	403 / 406
prostate	100%	518.01	245 / 245	99%	20.17	498 / 502
breast	100%	464.04	459 / 459	99%	17.66	1108 / 1118
pancreas	99%	280.51	325 / 328	100%	15.37	178 / 178
intestine	100%	496.46	966 / 966	98%	15.57	518 / 527
bladder	100%	488.00	21 / 21	98%	18.60	495 / 504
adrenal gland	99%	543.16	256 / 258	99%	16.71	227 / 230
esophagus	100%	452.04	1444 / 1445	98%	11.64	179 / 183
stomach	100%	383.76	358 / 359	98%	13.52	279 / 286
lung	98%	346.48	564 / 578	99%	16.92	1147 / 1155
eye	0%	0	0 / 0	100%	22.04	80 / 80
lymph node	0%	0	0 / 0	100%	22.86	29 / 29
spleen	100%	679.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.13	45 / 45
ureter	0%	0	0 / 0	100%	17.69	1 / 1
adipose	100%	395.17	1202 / 1204	0%	0	0 / 0
blood vessel	100%	412.49	1330 / 1335	0%	0	0 / 0
muscle	99%	327.14	797 / 803	0%	0	0 / 0
peripheral blood	98%	483.84	910 / 929	0%	0	0 / 0
heart	97%	279.30	832 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0045814	Biological process	negative regulation of gene expression, epigenetic
GO_0006482	Biological process	protein demethylation
GO_0070988	Biological process	demethylation
GO_0141137	Biological process	positive regulation of gene expression, epigenetic
GO_0031032	Biological process	actomyosin structure organization
GO_0036090	Biological process	cleavage furrow ingression
GO_0005730	Cellular component	nucleolus
GO_0030496	Cellular component	midbody
GO_0070938	Cellular component	contractile ring
GO_0005737	Cellular component	cytoplasm
GO_0032451	Molecular function	demethylase activity
GO_0035516	Molecular function	broad specificity oxidative DNA demethylase activity
GO_0016706	Molecular function	2-oxoglutarate-dependent dioxygenase activity
GO_0141131	Molecular function	DNA N6-methyladenine demethylase activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0046872	Molecular function	metal ion binding
GO_0140457	Molecular function	protein demethylase activity
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

Gene name	ALKBH4
Protein name	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-)
Synonyms	ABH4
Description	FUNCTION: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes . Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration . In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). .
Accessions	ENST00000490528.1 [Q9NXW9-2] ENST00000292566.4 [Q9NXW9-1] Q9NXW9

ALKBH4 report