I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 5% | |
| GABAergic neuron | 3 studies | 26% ± 7% | |
| glutamatergic neuron | 3 studies | 34% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 20% ± 5% | |
| GABAergic neuron | 3 studies | 26% ± 7% | |
| glutamatergic neuron | 3 studies | 34% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1153.06 | 245 / 245 | 100% | 36.09 | 502 / 502 |
| skin | 100% | 1178.67 | 1809 / 1809 | 100% | 32.65 | 472 / 472 |
| thymus | 100% | 863.58 | 653 / 653 | 100% | 25.60 | 605 / 605 |
| ovary | 100% | 1127.68 | 180 / 180 | 100% | 21.96 | 429 / 430 |
| kidney | 100% | 761.51 | 89 / 89 | 100% | 20.00 | 898 / 901 |
| adrenal gland | 100% | 796.49 | 258 / 258 | 100% | 23.67 | 229 / 230 |
| brain | 99% | 641.71 | 2621 / 2642 | 100% | 24.37 | 705 / 705 |
| stomach | 100% | 822.31 | 359 / 359 | 99% | 21.73 | 283 / 286 |
| pancreas | 100% | 664.40 | 327 / 328 | 99% | 21.29 | 176 / 178 |
| bladder | 100% | 1017.05 | 21 / 21 | 98% | 22.92 | 496 / 504 |
| breast | 100% | 1114.20 | 459 / 459 | 98% | 25.66 | 1094 / 1118 |
| lung | 99% | 754.51 | 571 / 578 | 98% | 23.64 | 1137 / 1155 |
| intestine | 100% | 899.05 | 966 / 966 | 97% | 23.32 | 512 / 527 |
| esophagus | 100% | 878.05 | 1445 / 1445 | 96% | 20.12 | 175 / 183 |
| liver | 100% | 499.52 | 226 / 226 | 93% | 13.30 | 378 / 406 |
| uterus | 100% | 1198.31 | 170 / 170 | 93% | 23.95 | 426 / 459 |
| adipose | 100% | 1032.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 985.50 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 30.09 | 80 / 80 |
| spleen | 100% | 988.15 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 26.32 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.96 | 1 / 1 |
| muscle | 100% | 1124.66 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 498.36 | 839 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 20.54 | 26 / 29 |
| peripheral blood | 82% | 493.48 | 765 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006307 | Biological process | DNA alkylation repair |
| GO_0008283 | Biological process | cell population proliferation |
| GO_2000766 | Biological process | negative regulation of cytoplasmic translation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0035515 | Molecular function | oxidative RNA demethylase activity |
| GO_0008198 | Molecular function | ferrous iron binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0031418 | Molecular function | L-ascorbic acid binding |
| GO_1990930 | Molecular function | mRNA N1-methyladenosine dioxygenase activity |
| GO_0035516 | Molecular function | broad specificity oxidative DNA demethylase activity |
| Gene name | ALKBH3 |
| Protein name | AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) |
| Synonyms | ABH3 DEPC1 |
| Description | FUNCTION: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) . Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation . Has a strong preference for single-stranded DNA . Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 . Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA . Also acts on RNA . Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons . Requires molecular oxygen, alpha-ketoglutarate and iron . . |
| Accessions | E9PSA5 ENST00000524742.5 ENST00000532129.1 E9PN35 ENST00000302708.9 [Q96Q83-1] ENST00000532962.5 E9PRD0 H0YDH4 Q96Q83 E9PRJ2 ENST00000534171.5 ENST00000530803.5 [Q96Q83-2] ENST00000529366.5 |
