ALKBH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0001701Biological processin utero embryonic development
GO_0050918Biological processpositive chemotaxis
GO_0031175Biological processneuron projection development
GO_0002101Biological processtRNA wobble cytosine modification
GO_0001764Biological processneuron migration
GO_0141137Biological processpositive regulation of gene expression, epigenetic
GO_0070129Biological processregulation of mitochondrial translation
GO_0001890Biological processplacenta development
GO_0006307Biological processDNA alkylation repair
GO_0006446Biological processregulation of translational initiation
GO_0042245Biological processRNA repair
GO_0006448Biological processregulation of translational elongation
GO_0035513Biological processoxidative RNA demethylation
GO_0048589Biological processdevelopmental growth
GO_1990983Biological processregulation of translational initiation by tRNA modification
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0005739Cellular componentmitochondrion
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140078Molecular functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity
GO_0035516Molecular functionbroad specificity oxidative DNA demethylase activity
GO_0008198Molecular functionferrous iron binding
GO_0035515Molecular functionoxidative RNA demethylase activity
GO_0042056Molecular functionchemoattractant activity
GO_0141131Molecular functionDNA N6-methyladenine demethylase activity
GO_0000049Molecular functiontRNA binding
GO_1990984Molecular functiontRNA demethylase activity

IV. Literature review

[source]
Gene nameALKBH1
Protein nameALKBH1 protein
Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-)
AlkB homolog 1, histone H2A dioxygenase
SynonymsABH1
ABH
ALKBH
DescriptionFUNCTION: Dioxygenase that acts as on nucleic acids, such as DNA and tRNA . Requires molecular oxygen, alpha-ketoglutarate and iron . A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment . Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs . Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation . In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position . mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation . Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA . N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Demethylates mRNAs containing N(3)-methylcytidine modification . Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity . Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites . DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product . DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity). .

AccessionsQ5XKL0
ENST00000555100.1
ENST00000216489.8
Q13686
H0YJF3
G3V4M4
ENST00000557057.5