Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell of proximal tubule | 5 studies | 28% ± 5% |
Insufficient scRNA-seq data for expression of ALDH4A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4013.07 | 244 / 245 | 100% | 105.26 | 500 / 502 |
liver | 100% | 34836.39 | 226 / 226 | 99% | 261.82 | 400 / 406 |
brain | 98% | 5753.13 | 2587 / 2642 | 100% | 115.23 | 702 / 705 |
kidney | 100% | 24066.97 | 89 / 89 | 91% | 89.06 | 820 / 901 |
bladder | 100% | 3043.67 | 21 / 21 | 89% | 57.80 | 450 / 504 |
skin | 95% | 1821.06 | 1722 / 1809 | 90% | 46.79 | 425 / 472 |
breast | 97% | 3434.44 | 443 / 459 | 87% | 41.52 | 972 / 1118 |
esophagus | 99% | 3061.51 | 1432 / 1445 | 84% | 31.92 | 154 / 183 |
uterus | 94% | 1438.81 | 159 / 170 | 89% | 41.63 | 409 / 459 |
stomach | 93% | 1472.21 | 335 / 359 | 75% | 30.79 | 214 / 286 |
adrenal gland | 100% | 2425.53 | 257 / 258 | 52% | 27.04 | 119 / 230 |
intestine | 70% | 804.90 | 676 / 966 | 81% | 36.76 | 428 / 527 |
lung | 72% | 919.14 | 417 / 578 | 69% | 22.62 | 799 / 1155 |
ovary | 77% | 1023.26 | 139 / 180 | 57% | 14.82 | 244 / 430 |
thymus | 88% | 1188.36 | 577 / 653 | 42% | 28.33 | 253 / 605 |
muscle | 100% | 5364.81 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 53.25 | 1 / 1 |
tonsil | 0% | 0 | 0 / 0 | 98% | 46.35 | 44 / 45 |
adipose | 96% | 3910.87 | 1161 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 95% | 1840.46 | 1272 / 1335 | 0% | 0 | 0 / 0 |
heart | 92% | 2368.33 | 791 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 55.84 | 73 / 80 |
spleen | 90% | 1173.47 | 218 / 241 | 0% | 0 | 0 / 0 |
pancreas | 9% | 83.09 | 30 / 328 | 45% | 11.67 | 80 / 178 |
peripheral blood | 25% | 313.71 | 231 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 2.53 | 3 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010133 | Biological process | proline catabolic process to glutamate |
GO_0019470 | Biological process | 4-hydroxyproline catabolic process |
GO_0006560 | Biological process | proline metabolic process |
GO_0006562 | Biological process | proline catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0004029 | Molecular function | aldehyde dehydrogenase (NAD+) activity |
GO_0003842 | Molecular function | 1-pyrroline-5-carboxylate dehydrogenase activity |
GO_0005515 | Molecular function | protein binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0009055 | Molecular function | electron transfer activity |
Gene name | ALDH4A1 |
Protein name | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) Aldehyde dehydrogenase 4 family member A1 |
Synonyms | ALDH4 P5CDH |
Description | FUNCTION: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. . |
Accessions | P30038 ENST00000375341.8 [P30038-1] Q5TF55 ENST00000538309.5 [P30038-2] ENST00000432718.1 ENST00000290597.9 [P30038-1] ENST00000538839.5 [P30038-3] |