AKT1S1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AKT1S1 at tissue level.

III. Associated gene sets

GO_0032007Biological processnegative regulation of TOR signaling
GO_0042981Biological processregulation of apoptotic process
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0045792Biological processnegative regulation of cell size
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0043523Biological processregulation of neuron apoptotic process
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031931Cellular componentTORC1 complex
GO_0005737Cellular componentcytoplasm
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKT1S1
Protein nameAKT1 substrate 1
Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
SynonymsPRAS40
DescriptionFUNCTION: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site . In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 . Its activity is dependent on its phosphorylation state and binding to 14-3-3 . May also play a role in nerve growth factor-mediated neuroprotection (By similarity). .

AccessionsENST00000391832.7 [Q96B36-1]
ENST00000391834.6 [Q96B36-1]
ENST00000391831.5 [Q96B36-1]
ENST00000391835.1 [Q96B36-3]
ENST00000391833.5 [Q96B36-1]
ENST00000599525.1
M0R2V8
ENST00000391830.1
ENST00000344175.10 [Q96B36-1]
H9KV91
Q96B36