AK6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AK6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AK6 at tissue level.

III. Associated gene sets

GO_0046940Biological processnucleoside monophosphate phosphorylation
GO_0042274Biological processribosomal small subunit biogenesis
GO_0015949Biological processnucleobase-containing small molecule interconversion
GO_0006364Biological processrRNA processing
GO_0015030Cellular componentCajal body
GO_0016607Cellular componentnuclear speck
GO_0005730Cellular componentnucleolus
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004017Molecular functionadenylate kinase activity
GO_0050145Molecular functionnucleoside monophosphate kinase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameAK6
Protein nameAdenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Adrenal gland protein AD-004) (Coilin-interacting nuclear ATPase protein) (hCINAP) (Dual activity adenylate kinase/ATPase) (AK/ATPase)
Adenylate kinase 6 (Adenylate kinase isoenzyme 6)
SynonymsCINAP
AD-004
CGI-137
DescriptionFUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity . Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation . While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (By similarity). Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation . .

AccessionsD6RDH4
Q9Y3D8
ENST00000380818.7 [Q9Y3D8-2]
ENST00000380822.9 [Q9Y3D8-1]
A0A087WY94
ENST00000612207.4 [Q9Y3D8-1]
ENST00000620269.4 [Q9Y3D8-2]
ENST00000618980.1
ENST00000502819.5
A0A087WVD7
ENST00000625009.1
ENST00000617079.4
ENST00000512561.5
ENST00000618233.4