AK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046039Biological processGTP metabolic process
GO_0046034Biological processATP metabolic process
GO_0046940Biological processnucleoside monophosphate phosphorylation
GO_0006172Biological processADP biosynthetic process
GO_0015949Biological processnucleobase-containing small molecule interconversion
GO_0046033Biological processAMP metabolic process
GO_0002082Biological processregulation of oxidative phosphorylation
GO_0009142Biological processnucleoside triphosphate biosynthetic process
GO_0009188Biological processribonucleoside diphosphate biosynthetic process
GO_0071456Biological processcellular response to hypoxia
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0046899Molecular functionnucleoside triphosphate adenylate kinase activity
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0004017Molecular functionadenylate kinase activity
GO_0050145Molecular functionnucleoside monophosphate kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAK4
Protein nameAdenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)
Adenylate kinase 4
nucleoside-diphosphate kinase (EC 2.7.4.6)
SynonymsAK3L1
AK3
hCG_2031840
DescriptionFUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates . Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor . Also displays broad nucleoside diphosphate kinase activity . Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK . Plays a protective role in the cellular response to oxidative stress . .

FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. .

AccessionsP27144
ENST00000395334.6
ENST00000546702.5
ENST00000327299.8
F8VS11
ENST00000545314.5
A0A384N647
K4Q5R3