AGBL1 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	39% ± 14%	Explore
type II pneumocyte	3 studies	52% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of AGBL1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
muscle	100%	1723.95	802 / 803	0%	0	0 / 0
brain	66%	166.85	1743 / 2642	3%	0.04	19 / 705
lung	34%	25.68	196 / 578	1%	0.04	16 / 1155
prostate	21%	27.70	52 / 245	4%	0.08	18 / 502
uterus	2%	1.45	4 / 170	2%	0.11	10 / 459
tonsil	0%	0	0 / 0	2%	0.05	1 / 45
esophagus	1%	2.87	16 / 1445	1%	0.01	1 / 183
kidney	0%	0	0 / 89	1%	0.04	13 / 901
ovary	1%	0.41	2 / 180	0%	0.00	1 / 430
thymus	1%	1.23	5 / 653	0%	0.00	2 / 605
breast	1%	1.31	3 / 459	0%	0.01	4 / 1118
peripheral blood	1%	0.34	7 / 929	0%	0	0 / 0
skin	0%	1.56	8 / 1809	0%	0.01	1 / 472
stomach	0%	0.11	1 / 359	0%	0.00	1 / 286
intestine	1%	0.22	5 / 966	0%	0	0 / 527
adipose	0%	0.35	6 / 1204	0%	0	0 / 0
adrenal gland	0%	0.16	1 / 258	0%	0	0 / 230
blood vessel	0%	0.30	4 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
pancreas	0%	0	0 / 328	0%	0	0 / 178
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0035609	Biological process	C-terminal protein deglutamylation
GO_0006508	Biological process	proteolysis
GO_0035610	Biological process	protein side chain deglutamylation
GO_0005829	Cellular component	cytosol
GO_0008270	Molecular function	zinc ion binding
GO_0015631	Molecular function	tubulin binding
GO_0004181	Molecular function	metallocarboxypeptidase activity

Gene name	AGBL1
Protein name	Cytosolic carboxypeptidase 4 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 1) (Protein deglutamylase CCP4) tubulin-glutamate carboxypeptidase (EC 3.4.17.24)
Synonyms	CCP4
Description	FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. .
Accessions	ENST00000441037.7 Q96MI9 A0A1B0GVQ2 ENST00000614907.3

AGBL1 report