AGAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0090630Biological processactivation of GTPase activity
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0030036Biological processactin cytoskeleton organization
GO_0016197Biological processendosomal transport
GO_0015031Biological processprotein transport
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0090543Cellular componentFlemming body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0141038Molecular functionphosphatidylinositol 3-kinase activator activity
GO_0035014Molecular functionphosphatidylinositol 3-kinase regulator activity
GO_0019901Molecular functionprotein kinase binding
GO_0005096Molecular functionGTPase activator activity
GO_0005525Molecular functionGTP binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameAGAP2
Protein nameArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
SynonymsCENTG1
KIAA0167
DescriptionFUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. .

AccessionsJ3KNM6
H0YHB1
Q99490
ENST00000547588.6
F8VVT9
ENST00000549129.1
ENST00000328568.9
ENST00000257897.7 [Q99490-2]