AEN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AEN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AEN at tissue level.

III. Associated gene sets

GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006259Biological processDNA metabolic process
GO_0010212Biological processresponse to ionizing radiation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0004529Molecular functionDNA exonuclease activity
GO_0004527Molecular functionexonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameAEN
Protein nameAlternative protein AEN
Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)
Apoptosis enhancing nuclease
SynonymsSBBI58
ISG20L1
DescriptionFUNCTION: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. .

AccessionsH0YMJ6
ENST00000332810.4 [Q8WTP8-1]
Q8WTP8
L8EB49
ENST00000559528.1