ADPRS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADPRS at tissue level.

III. Associated gene sets

GO_0140290Biological processpeptidyl-serine ADP-deribosylation
GO_0006281Biological processDNA repair
GO_0060546Biological processnegative regulation of necroptotic process
GO_0071451Biological processcellular response to superoxide
GO_0006287Biological processbase-excision repair, gap-filling
GO_0090734Cellular componentsite of DNA damage
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004649Molecular functionpoly(ADP-ribose) glycohydrolase activity
GO_0140292Molecular functionADP-ribosylserine hydrolase activity
GO_0061463Molecular functionO-acetyl-ADP-ribose deacetylase activity
GO_0004553Molecular functionhydrolase activity, hydrolyzing O-glycosyl compounds
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameADPRS
Protein nameADP-ribosylhydrolase ARH3 (EC 3.2.1.143) (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (Poly(ADP-ribose) glycohydrolase ARH3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase)
ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)
SynonymsARH3
hCG_38289
ADPRHL2
DescriptionFUNCTION: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose . Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response . Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage . Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds . Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos . Also hydrolyzes free poly(ADP-ribose) in mitochondria . Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins . Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers . .

AccessionsENST00000373178.5
Q9NX46
B7ZAN4