ADH4 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	4 studies	66% ± 10%	Explore
endothelial cell	3 studies	21% ± 6%	Explore

Name	Number of supported studies	Average coverage
liver	3 studies	33% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	58059.81	226 / 226	92%	592.66	372 / 406
esophagus	87%	231.89	1256 / 1445	16%	1.82	30 / 183
breast	89%	482.50	407 / 459	4%	0.09	42 / 1118
adipose	78%	150.60	945 / 1204	0%	0	0 / 0
intestine	45%	34.47	435 / 966	33%	4.69	172 / 527
stomach	37%	40.45	133 / 359	40%	6.27	115 / 286
adrenal gland	71%	77.77	182 / 258	5%	1.81	12 / 230
blood vessel	69%	114.66	917 / 1335	0%	0	0 / 0
kidney	62%	62.17	55 / 89	5%	2.54	44 / 901
thymus	44%	41.49	286 / 653	1%	0.01	4 / 605
spleen	41%	62.32	100 / 241	0%	0	0 / 0
muscle	41%	34.82	333 / 803	0%	0	0 / 0
skin	38%	39.62	696 / 1809	2%	0.18	11 / 472
pancreas	6%	2.41	20 / 328	34%	2.46	61 / 178
lung	29%	20.14	167 / 578	11%	1.28	122 / 1155
uterus	33%	30.02	56 / 170	3%	0.14	16 / 459
prostate	34%	30.39	83 / 245	2%	0.07	11 / 502
bladder	14%	4.76	3 / 21	16%	0.91	83 / 504
peripheral blood	23%	129.97	213 / 929	0%	0	0 / 0
ovary	17%	7.53	31 / 180	1%	0.01	3 / 430
heart	9%	6.45	75 / 861	0%	0	0 / 0
brain	1%	0.87	37 / 2642	1%	0.02	8 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046294	Biological process	formaldehyde catabolic process
GO_0046164	Biological process	alcohol catabolic process
GO_0006067	Biological process	ethanol metabolic process
GO_0006066	Biological process	alcohol metabolic process
GO_0010430	Biological process	fatty acid omega-oxidation
GO_1901661	Biological process	quinone metabolic process
GO_0001523	Biological process	retinoid metabolic process
GO_0006081	Biological process	cellular aldehyde metabolic process
GO_0042572	Biological process	retinol metabolic process
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0003960	Molecular function	NADPH:quinone reductase activity
GO_0016620	Molecular function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO_0004032	Molecular function	aldose reductase (NADPH) activity
GO_0004024	Molecular function	alcohol dehydrogenase (NAD+) activity, zinc-dependent
GO_0051287	Molecular function	NAD binding
GO_0019841	Molecular function	retinol binding
GO_0019115	Molecular function	benzaldehyde dehydrogenase [NAD(P)+] activity
GO_0004022	Molecular function	alcohol dehydrogenase (NAD+) activity
GO_0051903	Molecular function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
GO_0008270	Molecular function	zinc ion binding
GO_0004745	Molecular function	all-trans-retinol dehydrogenase (NAD+) activity
GO_0005503	Molecular function	all-trans retinal binding
GO_0005515	Molecular function	protein binding

Gene name	ADH4
Protein name	Alcohol dehydrogenase 4 (class II), pi polypeptide All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)
Synonyms	ADH2
Description	FUNCTION: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol . Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate . Also catalyzes the reduction of benzoquinones . .
Accessions	ENST00000504894.1 H0Y9N0 D6RIB1 ENST00000512499.5 ENST00000265512.12 [P08319-1] ENST00000505590.5 [P08319-2] D6R9K8 ENST00000506705.5 D6RF43 ENST00000504125.1 ENST00000509471.5 ENST00000508393.5 [P08319-2] P08319

ADH4 report