ADCY2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019933Biological processcAMP-mediated signaling
GO_0006171Biological processcAMP biosynthetic process
GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_1904322Biological processcellular response to forskolin
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005737Cellular componentcytoplasm
GO_0030425Cellular componentdendrite
GO_0030145Molecular functionmanganese ion binding
GO_0008179Molecular functionadenylate cyclase binding
GO_0004016Molecular functionadenylate cyclase activity
GO_0005524Molecular functionATP binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameADCY2
Protein nameadenylate cyclase (EC 4.6.1.1)
Adenylate cyclase 2
Adenylyl cyclase type II
Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)
SynonymsKIAA1060
DescriptionFUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling . Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). .

AccessionsENST00000493243.5
ENST00000515681.1
D6REB8
Q08462
ENST00000338316.9 [Q08462-1]
Q7RTV6
H0YA58