Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 18 studies | 66% ± 25% | |
glutamatergic neuron | 12 studies | 53% ± 26% | |
oligodendrocyte precursor cell | 11 studies | 37% ± 15% | |
GABAergic neuron | 10 studies | 53% ± 27% | |
retina horizontal cell | 6 studies | 60% ± 21% | |
endothelial cell | 5 studies | 40% ± 18% | |
neuron | 4 studies | 27% ± 12% | |
retinal cone cell | 4 studies | 41% ± 9% | |
interneuron | 4 studies | 62% ± 30% | |
GABAergic interneuron | 3 studies | 70% ± 2% | |
ependymal cell | 3 studies | 74% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 15 studies | 40% ± 24% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 6111.09 | 2620 / 2642 | 99% | 34.19 | 701 / 705 |
prostate | 97% | 1752.93 | 238 / 245 | 89% | 3.55 | 446 / 502 |
skin | 66% | 835.86 | 1191 / 1809 | 39% | 3.13 | 184 / 472 |
muscle | 100% | 7766.61 | 803 / 803 | 0% | 0 | 0 / 0 |
uterus | 79% | 1137.09 | 135 / 170 | 15% | 0.84 | 67 / 459 |
breast | 39% | 459.07 | 179 / 459 | 45% | 1.91 | 501 / 1118 |
ovary | 71% | 744.39 | 127 / 180 | 8% | 0.17 | 33 / 430 |
adrenal gland | 4% | 36.95 | 11 / 258 | 62% | 3.79 | 142 / 230 |
esophagus | 49% | 534.45 | 710 / 1445 | 10% | 0.22 | 18 / 183 |
intestine | 52% | 635.92 | 500 / 966 | 4% | 0.09 | 22 / 527 |
bladder | 38% | 425.57 | 8 / 21 | 4% | 0.16 | 22 / 504 |
blood vessel | 41% | 389.60 | 546 / 1335 | 0% | 0 | 0 / 0 |
kidney | 1% | 10.27 | 1 / 89 | 36% | 1.20 | 326 / 901 |
stomach | 24% | 254.68 | 86 / 359 | 12% | 0.37 | 33 / 286 |
pancreas | 0% | 0 | 0 / 328 | 31% | 0.83 | 56 / 178 |
eye | 0% | 0 | 0 / 0 | 24% | 0.60 | 19 / 80 |
adipose | 18% | 191.43 | 216 / 1204 | 0% | 0 | 0 / 0 |
lung | 1% | 6.02 | 5 / 578 | 16% | 0.63 | 181 / 1155 |
tonsil | 0% | 0 | 0 / 0 | 16% | 0.51 | 7 / 45 |
thymus | 1% | 4.55 | 4 / 653 | 10% | 0.56 | 59 / 605 |
liver | 0% | 0 | 0 / 226 | 1% | 0.01 | 3 / 406 |
peripheral blood | 0% | 0.67 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0019933 | Biological process | cAMP-mediated signaling |
GO_0006171 | Biological process | cAMP biosynthetic process |
GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
GO_1904322 | Biological process | cellular response to forskolin |
GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
GO_0016020 | Cellular component | membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0005737 | Cellular component | cytoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0030145 | Molecular function | manganese ion binding |
GO_0008179 | Molecular function | adenylate cyclase binding |
GO_0004016 | Molecular function | adenylate cyclase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0000287 | Molecular function | magnesium ion binding |
Gene name | ADCY2 |
Protein name | adenylate cyclase (EC 4.6.1.1) Adenylate cyclase 2 Adenylyl cyclase type II Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) |
Synonyms | KIAA1060 |
Description | FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling . Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). . |
Accessions | ENST00000493243.5 ENST00000515681.1 D6REB8 Q08462 ENST00000338316.9 [Q08462-1] Q7RTV6 H0YA58 |