ADCY10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ADCY10 at tissue level.

III. Associated gene sets

GO_1903378Biological processpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_1901524Biological processregulation of mitophagy
GO_1905461Biological processpositive regulation of vascular associated smooth muscle cell apoptotic process
GO_0006171Biological processcAMP biosynthetic process
GO_0051901Biological processpositive regulation of mitochondrial depolarization
GO_0045773Biological processpositive regulation of axon extension
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0006007Biological processglucose catabolic process
GO_1990535Biological processneuron projection maintenance
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_0045819Biological processpositive regulation of glycogen catabolic process
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0003351Biological processepithelial cilium movement involved in extracellular fluid movement
GO_0060306Biological processregulation of membrane repolarization
GO_0035556Biological processintracellular signal transduction
GO_0010917Biological processnegative regulation of mitochondrial membrane potential
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0106028Biological processneuron projection retraction
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_1990138Biological processneuron projection extension
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0106135Biological processnegative regulation of cardiac muscle cell contraction
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0045778Biological processpositive regulation of ossification
GO_0007286Biological processspermatid development
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0045178Cellular componentbasal part of cell
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0031514Cellular componentmotile cilium
GO_0043025Cellular componentneuronal cell body
GO_0097450Cellular componentastrocyte end-foot
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0090724Cellular componentcentral region of growth cone
GO_0005634Cellular componentnucleus
GO_0004016Molecular functionadenylate cyclase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030145Molecular functionmanganese ion binding
GO_0005524Molecular functionATP binding
GO_0051117Molecular functionATPase binding
GO_0071890Molecular functionbicarbonate binding

IV. Literature review

[source]
Gene nameADCY10
Protein nameAdenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase)
Adenylate cyclase 10
SynonymsSAC
DescriptionFUNCTION: Catalyzes the formation of the signaling molecule cAMP . May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels . Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation . .

AccessionsENST00000367851.9 [Q96PN6-1]
ENST00000485964.5
V9GY51
ENST00000545172.5 [Q96PN6-4]
U3KPS9
Q96PN6
ENST00000476818.2
ENST00000367848.1 [Q96PN6-2]