ACVR2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	10 studies	40% ± 23%	Explore
endothelial cell	9 studies	25% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	28% ± 11%	Explore
GABAergic neuron	7 studies	43% ± 18%	Explore
neuron	6 studies	34% ± 17%	Explore
interneuron	6 studies	42% ± 16%	Explore
macrophage	6 studies	27% ± 2%	Explore
astrocyte	5 studies	24% ± 11%	Explore
epithelial cell	4 studies	36% ± 14%	Explore
GABAergic interneuron	3 studies	25% ± 10%	Explore
microglial cell	3 studies	19% ± 3%	Explore
progenitor cell	3 studies	27% ± 6%	Explore
retinal cone cell	3 studies	24% ± 8%	Explore
fibroblast	3 studies	24% ± 6%	Explore
basal cell	3 studies	33% ± 21%	Explore
adipocyte	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	32% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1162.73	245 / 245	100%	10.02	500 / 502
bladder	100%	1571.00	21 / 21	99%	8.54	499 / 504
lung	100%	1002.54	576 / 578	99%	7.44	1147 / 1155
esophagus	100%	1419.16	1445 / 1445	99%	8.01	181 / 183
breast	100%	1397.03	459 / 459	97%	7.96	1089 / 1118
pancreas	98%	572.96	322 / 328	99%	9.30	176 / 178
stomach	100%	943.67	359 / 359	97%	6.38	277 / 286
intestine	100%	1198.92	966 / 966	97%	6.48	510 / 527
thymus	100%	1079.87	652 / 653	97%	7.29	585 / 605
kidney	100%	658.98	89 / 89	96%	6.74	864 / 901
uterus	100%	1184.48	170 / 170	96%	8.55	440 / 459
ovary	100%	924.32	180 / 180	95%	5.70	409 / 430
brain	93%	766.49	2451 / 2642	99%	7.81	701 / 705
adrenal gland	99%	551.12	255 / 258	90%	6.15	208 / 230
skin	100%	2953.37	1809 / 1809	89%	5.93	421 / 472
liver	100%	531.02	226 / 226	83%	3.85	336 / 406
adipose	100%	1415.48	1204 / 1204	0%	0	0 / 0
spleen	100%	772.05	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.30	1 / 1
blood vessel	100%	836.69	1333 / 1335	0%	0	0 / 0
muscle	99%	628.43	796 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	8.02	44 / 45
heart	93%	451.28	800 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	2.35	22 / 29
eye	0%	0	0 / 0	65%	2.81	52 / 80
peripheral blood	9%	32.80	88 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0007498	Biological process	mesoderm development
GO_0032924	Biological process	activin receptor signaling pathway
GO_0007178	Biological process	cell surface receptor protein serine/threonine kinase signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0071773	Biological process	cellular response to BMP stimulus
GO_0045428	Biological process	regulation of nitric oxide biosynthetic process
GO_0007368	Biological process	determination of left/right symmetry
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0042713	Biological process	sperm ejaculation
GO_0032927	Biological process	positive regulation of activin receptor signaling pathway
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0043084	Biological process	penile erection
GO_0030509	Biological process	BMP signaling pathway
GO_0060011	Biological process	Sertoli cell proliferation
GO_0048706	Biological process	embryonic skeletal system development
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0045648	Biological process	positive regulation of erythrocyte differentiation
GO_0006468	Biological process	protein phosphorylation
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001702	Biological process	gastrulation with mouth forming second
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0034673	Cellular component	inhibin-betaglycan-ActRII complex
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_0048179	Cellular component	activin receptor complex
GO_0015026	Molecular function	coreceptor activity
GO_0098821	Molecular function	BMP receptor activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0048185	Molecular function	activin binding
GO_0030165	Molecular function	PDZ domain binding
GO_0004675	Molecular function	transmembrane receptor protein serine/threonine kinase activity
GO_0017002	Molecular function	activin receptor activity
GO_0019838	Molecular function	growth factor binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0034711	Molecular function	inhibin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ACVR2A
Protein name	Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Synonyms	ACVR2
Description	FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A . Mediates induction of adipogenesis by GDF6 (By similarity). .
Accessions	ENST00000241416.12 [P27037-1] ENST00000404590.1 [P27037-1] P27037 ENST00000535787.5 [P27037-2]

ACVR2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review